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ANTI-AGING ACTIVITY OF THE GHK PEPTIDE - THE SKIN AND BEYOND
L. Pickart, A. Margolina
J Aging Res Clin Practice 2012;1(1):13-16
Show summaryHide summaryThe human copper binding peptide GHK has been extensively studied as a wound-healing agent and widely used in anti-aging cosmetic compositions. Recent studies demonstrated this substance has a broad range of anti-aging activity. GHK is normally used as its copper 2+ complex GHK-Cu which in low non-toxic concentrations facilitates skin healing and remodeling, reduces inflammatory mediators, and increases production of important growth factors and molecular regulators such as decorin. A series of facial studies conducted by different researchers demonstrated that GHK-Cu containing creams reduce signs of aging such as wrinkles, mottled pigmentation and skin laxity. Also, GHK-Cu increases the expression of epidermal stem cell markers such as integrins and p63. GHK-Cu also repairs DNA damage in irradiated fibroblasts restoring normal functions and growth. Recently GHK and plant alkaloid securinine, out of 1309 bioactive compounds tested, were found to suppress RNA production in 70% of 54 human genes overexpressed in patients with aggressive metastatic colon cancer. GHK-Cu possesses antioxidant activity, increasing the level of antioxidant enzymes, reducing proinflammatory cytokines and oxidative damage, as well as quenching toxic products of lipid peroxidation. In conclusion, the tripeptide GHK-Cu that has a long safety record in skin care formulations possesses a range of health benefits, including skin regeneration, repair of irradiated cells, maintenance of stem cells, as well as anti-inflammatory, antioxidant and anti-cancer activity.
OPEN ACCESSEVALUATING THE POTENTIAL BENEFITS OF CUCUMBERS FOR IMPROVED HEALTH AND SKIN CARE
H. Murad, M.A. Nyc
J Aging Res Clin Practice 2016;5(3):139-141
Show summaryHide summaryEpidemiological and nutritional studies indicate that cucumbers, a fruit in the cucurbitaceae family, have numerous benefits internally, externally and even emotionally. As a food, cucumbers offer superior hydration, as they are about 95% water. They have been used for decades for their anti-inflammatory benefits on skin, soothing properties for digestion, and other therapeutic uses. The following contribution offers an overview of cucumbers, specifically, their use to augment cellular water and address common conditions (i.e.: skin discoloration and aging, cardiovascular and cancerous diseases, bone health, inflammation, and connective tissue disorders).
CITATION:
H. Murad ; M.A. Nyc (2016): Evaluating the potential benefits of cucumbers for improved health and skin care. The Journal of Aging Research and Clinical Practice (JARCP). http://dx.doi.org/10.14283/jarcp.2016.108
SPECIFIC NATURAL BIOACTIVE TYPE 1 COLLAGEN PEPTIDES ORAL INTAKE REVERSE SKIN AGING SIGNS IN MATURE WOMEN
L. Duteil, C. Queille-Roussel, Y. Maubert, J. Esdaile, C. Bruno-Bonnet, J.-P. Lacour
J Aging Res Clin Practice 2016;5(2):84-92
Show summaryHide summaryObjective: To assess the anti-aging potential of three type I fish collagen hydrolysates (CH1=Naticol® BPMG, CH2=Naticol® HPMG, CH3=Naticol® 1000MG) on skin aging signs for three different body sites of mature women. Design: Double-blind, randomized and Placebo-controlled clinical study. Setting: Centre of Clinical Pharmacology Applied to Dermatology (CPCAD, Nice). Participants: Sixty women aged 46-69 years having skin aging signs on the face. Intervention: Participants were randomized to receive a once daily 5g dose of one of the CHs or Placebo for 8 weeks. Measurements: Skin biomechanics, skin hydration and visual assessment of the crow’s-feet wrinkles were evaluated after 4 and 8 weeks of treatment. Subject satisfaction questionnaire and Investigator global efficacy appreciation (IGEA) were also used. Results: Skin biomechanics indicated a significant improvement of skin firmness for the three CHs compared to Placebo, in particular for CH2. An increase of overall skin elasticity for CH3 (p = 0.017) and CH2 (p = 0.044) on the abdomen was also observed. This was corroborated by the significant decrease of the crow’s-feet wrinkle score at week 8 for both CH3 and CH2 (p=0.023 and p=0.014, respectively). Concerning the self-questionnaire, overall the number of positive responses was significantly higher for CH2 compared to Placebo and other CHs. For the IGEA, the number of favorable answers was greater for CH2 than for the Placebo group (80% vs. 36%, p= 0.025). A positive influence of CH treatments could be observed for skin hydration but failed to reach statistical significance. Conclusion: The tested type I fish collagen hydrolysates have beneficial effects on skin quality. In particular, CH2 demonstrated the greatest range of these effects including improvement of skin biomechanics, decrease of wrinkles, good subject satisfaction and no related adverse events.
CITATION:
L. Duteil ; C. Queille-Roussel ; Y. Maubert ; J. Esdaile ; C. Bruno-Bonnet ; J.-P. Lacour (2016): Specific natural bioactive type 1 collagen peptides oral intake reverse skin aging signs in mature women. The Journal of Aging Research and Clinical Practice (JARCP). http://dx.doi.org/10.14283/jarcp.2016.97
MID-UPPER ARM CIRCUMFERENCE (MUAC) FOR DETECTING MALNUTRITION IN HOSPITALIZED ELDERLY
V.A. Leandro-Merhi, M. Nicastro, J.L. Braga de Aquino
J Aging Res Clin Practice 2013;2(2):231-235
Show summaryHide summaryObjective: This study investigated the relationship between mid-upper arm circumference and other nutritional assessment indicators to be used as a tool for the nutritional diagnosis of the elderly. Methods: Anthropometry was used for the nutritional assessment of 123 hospitalized elderly patients with subsequent investigation of the relationship between mid-upper arm circumference (MUAC) and the other indicators. The Mann-Whitney test was used for comparing the data and the Spearman’s linear correlation coefficient was used for assessing the association between the variables. The receiver operator characteristic (ROC) curve was constructed for determining the cut-off. Results: A positive and significant correlation was found between MUAC and other indicators in the whole group and by gender, except between MUAC and waist-to-hip ratio. MUAC differed significantly from the other indicators, suggesting that MUAC can also be used as an indicator of malnutrition in this casuistic. For the construction of the ROC curve, the gold standard was risk estimated by body mass index since correlated best with MUAC. The ROC curve identified a cut-off point of 28.25 cm, with high sensitivity (87.10%) and high specificity (76.09%). Conclusion: The use of MUAC has practical implications for the nutritional assessment of hospitalized elderly, especially if a greater cut-off point is used for the population.
OPEN ACCESSDIETARY PATTERNS, NUTRIENT INTAKES, AND NUTRITIONAL AND PHYSICAL ACTIVITY STATUS OF SAUDI OLDER ADULTS: A NARRATIVE REVIEW
H. M. Alsufiani, T.A. Kumosani, D. Ford, J.C. Mathers
J Aging Res Clin Practice 2015;4(1):2-11
Show summaryHide summaryObjective: to review the dietary patterns, nutrient intakes, and nutritional and physical activity status of older adults living in Saudi Arabia, to examine geographical differences in such patterns and to identify research gaps in respect of nutrition and physical activity for this population group. Design: Databases and websites (including Pubmed, Scopus, Proquest, Google Scholar and Arab Center for Nutrition) were searched in English and Arabic languages using the following key words: nutritional status, dietary pattern, food pattern, dietary habits, micronutrient intake and status, macronutrients intake, obesity, malnutrition, iron deficiency anemia, vitamin D, physical activity, exercise, Saudi older adults and Saudi elderly. All relevant and available data for both free-living and institutionalized Saudi older adults (> 50 years old or with mean age > 50 years) published in the last 20 years were included in this review. Results: We found that free-living females consumed fewer meals, and less fruits and vegetables, but their reported energy intake was higher than for males. Low intake of vitamins C and D were common in both genders and in those who lived in western and northern regions while low intake of folate and fiber were common in institutionalized people. Omega-3 fatty acids and fish were more highly consumed by older adults living in the coastal region compared with residents in the internal region. Obesity, overweight, vitamin D deficiency and insufficiency and physical inactivity were prevalent in free living older adults throughout the country while underweight and iron deficiency anemia were prevalent in institutionalized persons. Conclusion: Information on dietary patterns, nutrient intakes, and nutritional and physical activity status of older adults living in Saudi Arabia is fragmentary and interpretation of the findings is hampered by the lack of population-representative sampling frames and the use of heterogeneous data collection tools. More systematic studies are essential to facilitate objective assessment of these important lifestyle-related factors and to inform public health policies.
CITATION:
H. M. Alsufiani ; T.A. Kumosani ; D. Ford ; J.C. Mather (2015): DIETARY PATTERNS, NUTRIENT INTAKES, AND NUTRITIONAL AND PHYSICAL ACTIVITY STATUS OF SAUDI OLDER ADULTS: A NARRATIVE REVIEW. The Journal of Aging Research and Clinical Practice (JARCP). http://dx.doi.org/10.14283/jarcp.2015.46